''There was a longer-lasting free radical effect in the wounds that had been treated with grape-seed extract. We think that's partly why acne healed faster and better without acne scarring.''
Grape-seed extract helps skin acne heal faster and with less acne scarring, a new study suggests.
Why we use grape seed-extract (Proanthocyanidin extract) as microbe base for acne product.
Speeds up acne skin healing.
Reduces chances of acne scaring.
Grape-seed extract helps skin acne heal faster and with less scarring, a new study suggests.
The extract seemed to aid skin healing in two ways: It helped the body make more of a compound used to regenerate damaged blood vessels, and it also increased the amount of free radicals in the wound site. Free radicals help clear potentially pathogenic bacteria from a wound.
In two related experiments, the researchers tested the effects of grape-seed extract on human skin cells. It's the first evidence suggesting that a natural extract could have such a profound effect on skin blemishes healing, said and director the Laboratory of Molecular Medicine.
''We saw the healing effects grape-seed extract had on wounds from day one,''saidprofessor of surgery at Ohio State. ''It seemed to enhance the formation of epidermal tissue as well as the deposition of connective tissue.''
The researchers treated skin wounds with a topical formulation of grape seed proanthocyanidin extract (GSPE). Proanthocyanidin, one of the main ingredients in grape-seed extract, is thought to be a potent antioxidant. But in a wound site, which is rich in free radicals, the extract assumes some pro-oxidant properties.
''The skin treated with grape-seed extract was further along in the healing process compared to the saline-treated tissue. ''The extract-treated skin showed signs of healing faster and the newly formed tissue was denser, meaning that its structure was stronger.''
The researchers saw increased levels of tenascin, a protein that helps build connective tissue, in the granulation tissue of the wounds treated with GSPE. Granulation tissue is the rough, pinkish tissue that normally forms as a wound heals. It contains new capillaries and connective tissue.
The researchers also noted increased levels of VEGF, the compound that helps the body rebuild blood vessels. In previous research found that GSPE helped turn on the gene responsible for initiating the making of VEGF.
In a related experiment, the researchers also treated human skin cells with GSPE, finding that the extract helped the laboratory-grown cells produce more VEGF.
More VEGF means blood vessels will form faster and that more nutrients will be carried by the blood to regenerate damaged tissue.
In addition to helping blood vessels regenerate, GSPE also seemed to increase free radical levels at the wound site. It may seem odd that an antioxidant could help oxidation - the formation of free radicals - flourish. But
Skin wounds are rich in free radicals. ''There was a longer-lasting free radical effect in the wounds that had been treated with grape-seed extract. Partly why these wounds healed faster and better.''
While grape-seed extract is good news for wounded tissue. And consumers shouldn’t expect to get the same wound-healing benefits from taking grape-seed extract in vitamin form.
''Taken orally, the extract functions like an antioxidant. ''But in a wound, where free radicals are abundant, that proanthocyanidin assumes pro-oxidant behavior.